Formulation development and characterization of curcumin loaded solid lipid nanoparticles for improved aqueous solubility and bioavailability
P Senthil Kumar and N Punniamurthy
Curcumin is a yellow hydrophobic polyphenol derived from the rhizome of turmeric that is safe and beneficial in several ailments. Low aqueous solubility and poor bioavailability were important of disadvantages of curcumin. The aim of the present study was to formulate the curcumin solid lipid nanoparticles (SLNs) with increased bioavailability profile and improved pharmacological activity. The SLNs were prepared by a hot homogenization coupled with ultrasonication method using tripalmitin, tween 80 and poly vinyl alcohol. The optimized blank SLNs formulations were utilized to entrap curcumin and characterized for particle size, polydispersity index, zeta potential, shape, drug encapsulation efficiency, and in vitro drug release. The prepared SLNs were analyzed by FT-IR spectroscopy to confirm the cross-linking reaction between drug, lipid and surfactants. The results demonstrated that the particle size, polydispersivity index, zeta potential, encapsulation efficiency and loading capacity of the SLNs were 214.60± 3.55nm, 0.49±0.03, -29.63±0.50mV, 51.99±4.14% and 5.33±0.34%, respectively. AFM images showed spherical to circular particles with well defined periphery. In vitro drug release exhibited biphasic pattern with an initial burst release of 16.5% within 2h followed by sustained release over 96h. FT-IR study suggested that during the process of formulations, lipid and surfactants have not reacted with the drug to give rise to reactant products and it was only physical mixture.
How to cite this article:
P Senthil Kumar, N Punniamurthy. Formulation development and characterization of curcumin loaded solid lipid nanoparticles for improved aqueous solubility and bioavailability. Pharma Innovation 2017;6(4):07-11.