Features of systemic immune-inflammatory response in children with pyelonephritis depending on the manifestations of undifferentiated connective tissue dysplasia
LV Melnychuk and OL Tsymbalista
Urinary tract infections are the most common in children under the age of 3 years ranking second among all infectious diseases. Pyelonephritis is a nonspecific bacterial inflammation of the kidney with predominantly focal tubulointerstitial damage and severe involvement of the renal calyces and pelvis. Pyelonephritis which occurs in children with modified somatic status is of special interest. Particular attention should be paid to undifferentiated connective tissue dysplasia (UCTD). The aim of the research was to study the effect of underlying UCTD on the features of systemic immune-inflammatory response in children with pyelonephritis. 160 children at the age of 3-15 years (the average age - 8.6±1.4 years) with pyelonephritis underwent clinical and laboratory examinations. There were 80 children with manifestations of UCTD and 80 children without manifestations of connective tissue dysplasia. The analysis of paraclinical indicators of systemic immune-inflammatory response in children with pyelonephritis revealed their significant activation in patients with underlying UCTD as well as in patients without it. The maximum deviations of the given parameters from normal values were detected in younger children (р<0.05). With age, the signs of cytokine burst reduced, however, they prevailed among children with UCTD of all age groups. The levels of tumor necrosis factor (TNF-α) and interleukin 8 (IL-8) increased in all age groups compared to healthy children (р<0.001). In children of both groups, alongside with the activation of pro-inflammatory response, an anti-inflammatory interleukin 10 (IL-10) increased as well (р<0.001). Thus, the severity of systemic immune-inflammatory response was higher in children with pyelonephritis and UCTD manifestations.
How to cite this article:
LV Melnychuk, OL Tsymbalista. Features of systemic immune-inflammatory response in children with pyelonephritis depending on the manifestations of undifferentiated connective tissue dysplasia. Pharma Innovation 2017;6(3):168-171.