Vol. 6, Issue 3 (2017)
Synthesis of new schiff bases and their transition metal complexes (CoII, NiII, CuII & ZnII) and their characterization stability constant and microbial activities
A series of Schiff bases have been synthesized by reacting 4(P-fluro phenyl) 2-aminothiazole and 2-Hydroxyacetophenone (R-H, 5-Me, 5-cl). The bases and their metal complexes were characterized by elemental analysis, UV-visible and Infra-red spectra, magnetic susceptibility and conductivity measurement. The Schiff base complexes act as monomeric and have octahedral in geometry. The ligand coordinated through oxygen atom of phenolic –OH group and the nitrogen atom of azomethine group. The complexes are non-electrolitic in nature. The stability constants and thermodynamic parameters (ΔH, ΔG & ΔS) were recorded. The –ve ΔG in each cases indicates the complexation is spontaneous. The enthalpy change is exothermic. The positive value of ΔS indicates the reactions are entropically favored. The Schiff bases and their metal complexes were screened for antibacterial, anti-fugal and pesticidal activity.
How to cite this article:
BN Muthal. Synthesis of new schiff bases and their transition metal complexes (CoII, NiII, CuII & ZnII) and their characterization stability constant and microbial activities. Pharma Innovation 2017;6(3):72-76.