Dynamics of features of heart rate variability with application of alpha-lipoic acid in patients with type 2 diabetes mellitus who have had myocardial infarction
N Altunina and V Lizogub
The article presents the dynamics of heart rate variability (HRV) features of 59 patients with type 2 diabetes mellitus (DM) who have had non-Q-myocardial infarction (non-Q-MI) under the influence of 4-month treatment of alfa-lipoic acid (ALA). Treatment showed a significant increase in high frequency activity HF (p<0.01), HFnorm (p<0.05) in the daytime with an increase in its contribution to the total spectral power – HF% (p<0.05). Besides, it was recorded a decrease in percentage contribution of low-frequency LFnorm% (p<0.001) and the growth of high-frequency HFnorm% activity (p<0.001) in the autonomic regulation of heart rate during the active period of time, which is reflected in sympathovagal interaction index LF/HF (p<0.001). Thus, the 4-month use of ALA in addition to the basic therapy of patients with type 2 DM who had non-Q-MI, causes positive effect on HRV, that includes the increase in the tone of the parasympathetic link of autonomic nervous system and normalizing of sympathovagal interaction in daytime.
How to cite this article:
N Altunina, V Lizogub. Dynamics of features of heart rate variability with application of alpha-lipoic acid in patients with type 2 diabetes mellitus who have had myocardial infarction. Pharma Innovation 2017;6(3):23-26.