Vol. 6, Issue 3 (2017)

Author(s):
N Altunina and V Lizogub

Abstract:
The article presents the dynamics of heart rate variability (HRV) features of 59 patients with type 2 diabetes mellitus (DM) who have had non-Q-myocardial infarction (non-Q-MI) under the influence of 4-month treatment of alfa-lipoic acid (ALA). Treatment showed a significant increase in high frequency activity HF (p<0.01), HFnorm (p<0.05) in the daytime with an increase in its contribution to the total spectral power – HF% (p<0.05). Besides, it was recorded a decrease in percentage contribution of low-frequency LFnorm% (p<0.001) and the growth of high-frequency HFnorm% activity (p<0.001) in the autonomic regulation of heart rate during the active period of time, which is reflected in sympathovagal interaction index LF/HF (p<0.001). Thus, the 4-month use of ALA in addition to the basic therapy of patients with type 2 DM who had non-Q-MI, causes positive effect on HRV, that includes the increase in the tone of the parasympathetic link of autonomic nervous system and normalizing of sympathovagal interaction in daytime.