1. To evaluate immunomodulatory activity of atorvastatin calcium by using host resistance model against E. coli induced sepsis in mice
2. To elucidate probable mechanism of action of immunomodulatory activity of atorvastatin calcium & septilin syrup.
Methods: Immunomodulatory activity of atorvastatin calcium was evaluated by using host resistance model against E.coli induced sepsis. The mechanism of action was studied in survived mice from sepsis, by studying histopathology of spleen, thymus along with evaluation of bone marrow.
Results: The atorvastatin calcium have increased the survival in sepsis induced mice & also decreased apoptosis of T & B cells by stimulating cellularity in PALS, marginal zone & follicles of spleen as well as cortex, medulla of thymus. The test drugs also increased myeloid+lymphoid cells in bone marrow. All the results were statistically significant as compared with control & were comparable with septilin syrup group which was used as positive control.
Conclusion: Pretreatment of atorvastatin calcium as well as Septilin syrup before induction of sepsis have shown prominent increase in the survival rate due to their immunostimulant activity.