The purpose of this study was to develop a sustained release floating drug delivery system (hollow microsphere or microballoons) of Verapamil hydrochloride using Ethyl cellulose and Eudragit RL 100. Microballoons were prepared by non – aqueous solvent evaporation method and optimized by changing drug: polymer ratio, and polymer combination. Thirteen batches containing only Ethyl Cellulose, only Eudragit RL 100 and both Ethyl Cellulose and Eudragit RL 100 were prepared and evaluated. Drug to Polymer ratio of 1:2 was found to be optimized.
Microballoons were stable, white colored, spherical, free flowing in nature and showed controlled release up to 12 hours. The drug release from the microballoons followed Higuchi model indicating diffusion controlled non-Fickian drug release. Optimized formulation batch showed percentage yield 80.99%, percentage buoyancy 84.05±0.93%, particle size 301.17±3.43µm and percentage drug entrapment efficiency 81.45 ± 0.21%.