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Vol. 6, Issue 12 (2017)

Design synthesis and evaluation of novel thiazolidinedione derivatives as antidiabetic agents

Author(s):
Kawade Dadasaheb, Nitin Jain, Jadhav Vijay and Girish Kashid
Abstract:
A Series of thiazolidinedione derivatives were synthesized by reacting 5-(4-hydroxybenzylidene)-1,3-thiazolidine-2,4-one and 5-(4-hydroxy-3-methoxybenzylidene)-1,3-thiazolidine-2,4-one with aromatic N-substituted acetamide at room temperature. Synthesized compounds were characterised by IR, 1H-NMR and mass spectroscopy and evaluated for antidiabetic activity in dexamethasone induced Wister albino mice animal model. Compound C and Compound D have exhibited promising hypoglycemic activity by comparing against Pioglitazone and metformin.
Pages: 390-398  |  420 Views  35 Downloads
How to cite this article:
Kawade Dadasaheb, Nitin Jain, Jadhav Vijay, Girish Kashid. Design synthesis and evaluation of novel thiazolidinedione derivatives as antidiabetic agents. Pharma Innovation 2017;6(12):390-398.
The Pharma Innovation Journal