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Vol. 6, Issue 12 (2017)

Evaluation of effect of acetaminophen and Eclipta alba. L extract on biochemical parameters on liver of Rattus rattus

Author(s):
Sumira Aziz and Mohd Ashraf Ganaie
Abstract:
The present study of the preliminary phyto chemical qualitative examination of acetaminophen (paracetamol) and aqueous extracts of Eclipta alba L. shows presence of different biochemical parameters, The various biochemical parameters namely SGOT, SGPT SALP serum, bilirubin and total protein were monitored in this study, because of their diagnostic significance and role in providing information concerning biochemical changes caused by acetaminophen (paracetamol) induced toxicity. The effect of Eclipta alba on biochemical parameters in control and acetaminophen induced hepatotoxic rats. Experimentally it has been shown to rise when acetaminophen (paracetamol) are given to rats. Administration of acetaminophen (750mg/kg; bodyweight), after 18 hours of intoxication resulted a significant (P<0.05) elevation of hepato-specific serum markers SGOT, SGPT, SALP, bilirubin and total protein in acetaminophen treated group, in comparison with the normal control group. On administration of CEEA and MEEA and Silymarin at the dose of 25mg/kg the level of these enzymes were found retrieving towards normalcy. While as at the 250mg/kg b.wt dose of eclipta alba methanol Extract showed highest percent of reduction in the cholesterol level (49.71%) followed by chloroform extract (27.16%) compared to acetaminophen treated rats. At 500mg/kg b.wt methanol extract showed (44.55%) and chloroform extract (23.91%) respectively. It should be noted that in all cases acetaminophen and plant extracts could not significantly changes the blood glucose level of rats
Pages: 149-156  |  627 Views  11 Downloads
How to cite this article:
Sumira Aziz, Mohd Ashraf Ganaie. Evaluation of effect of acetaminophen and Eclipta alba. L extract on biochemical parameters on liver of Rattus rattus. Pharma Innovation 2017;6(12):149-156.
The Pharma Innovation Journal