Effect of 2-ethyl-6-methyl-3-hydroxypyridine succinate on the retina with correction of paclitaxel-induced retinopathy in the experiment
NZ Dovga, SB Gerashchenko and OI Deltsova
In the experiment 72 white rats were injected with intraperitoneal Paclitaxel (Actavis, Romania) in the dose of 2 mg/kg body weight 4 times a day, the total dose of 8 mg/kg, followed by 48 animals injected intraperitoneally with 2-ethyl-6-methyl-3-hydroxypyridine succinate (armadin) in the dose of 10 mg/kg (in the control group 24 rats were treated with water for injection intraperitoneally). It was established that in case of paclitaxel-induced retinopathy corrected with armadin the morphometric parameters (thickness of the whole retina and its layers) from the 1st to the 28th day reveal a stable tendency to normalization, indicating the improvement of its morpho-functional state, the restoration of the layer the rods and cones, and the thickness of other layers approaching the standard indices. From the 60th day the positive influence of armadin on the retina fades, a gradual decrease in the thickness of the layer of rods and cones, outer nuclear, plexiform and ganglionic layers takes place. On the 120th day there may be observed signs of swelling in the outer and inner nuclear layers as well as the layer of nerve fibres. The thickness of the retina increases.
How to cite this article:
NZ Dovga, SB Gerashchenko, OI Deltsova. Effect of 2-ethyl-6-methyl-3-hydroxypyridine succinate on the retina with correction of paclitaxel-induced retinopathy in the experiment. Pharma Innovation 2017;6(11):781-784.