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Vol. 6, Issue 11 (2017)

Evaluation of antidiabetic effect of Murraya koenigii leaves chloroform extract (MKLCE) in alloxan induced diabetic albino rats

Author(s):
Ahmed SK, Sunil M, Chakrapani Cheekavolu and Naveen Alasyam
Abstract:
Background: Diabetes is a growing health concern in the world and is now emerging as an epidemic world over. Currently, more attention is being paid to the natural products study as potential antidiabetics. India is considered as the worlds diabetic capital. The study of plants having Antidiabetic activity may give a new idea in the approaches of diabetes mellitus treatment.
Objective: The present study was aimed to evaluate the antidiabetic effect of Murraya koenigii leaves chloroform extract (MKLCE) in alloxan ‑ induced diabetic albino rats model.
Methods: Albino rats weighing 150- 250 grams were grouped into 5 equal groups taking 6 rats in each. Group A served as control (normal), Group B as diabetic control, received alloxan after overnight fasting. Group C & D was received alloxan + MKLCE suspension at a doses of 250 & 500 mg/kg orally respectively, Group E was given alloxan + standard drug (Glimiperide 2mg/kg) suspension for 21 days & the MKLCE effect on blood sugar was measured at regular intervals. At the end of this research study blood samples were collected from all rats on 0day (initial), on day 7th, 14th, 21st of given test drug MKLCE treatment for biochemical estimation of blood sugar with glucometer & the FBS values were observed.
Results: This present research study revealed that MKLCE has antidiabetic effect against alloxan induced diabetic albino rats on i.p. alloxan injection at 120mg/kg.b.w. & confirms that on i.p. alloxan injection causes a significant raise in fasting blood sugar (FBS) in untreated albino rats when compared to control group. Treatment of diabetic rats with MKLCE for 21 days caused a dose dependent fall in FBS levels. Glimiperide treated diabetic rats also showed a significant (P<0.00) fall in FBS levels after 21 days of treatment.
Conclusion: It is concluded that MKLCE has shown significant antidiabetic effect at a doses of 250 & 500 mg/kg. b.w. in alloxan induced diabetic albino rats.
Pages: 474-477  |  820 Views  20 Downloads
How to cite this article:
Ahmed SK, Sunil M, Chakrapani Cheekavolu, Naveen Alasyam. Evaluation of antidiabetic effect of Murraya koenigii leaves chloroform extract (MKLCE) in alloxan induced diabetic albino rats. Pharma Innovation 2017;6(11):474-477.
The Pharma Innovation Journal