Vol. 6, Issue 11 (2017)

Author(s):
Natalia V Zhukova, Tatyana A Gloriozova, Vladimir V Poroikov and Valery M Dembitsky

Abstract:
The present review describes the biological activities of natural halogenated (Cl, Br and I) marine steroids. More than twenty biologically active steroids have shown confirmed anti-tumour, antibacterial, antiviral and other activities. The structures and reported and predicted activities of natural halogenated steroids are available. With the computer programme PASS and based on structure–activity relationships (SAR), some additional activities are also predicted, which point towards new possible applications of these lipids. This review emphasizes the role of natural halogenated steroids as an important source and potential leads for drug discovery and they are of great interest to chemists, physicians, biologists, pharmacologists and the pharmaceutical industry.