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Vol. 6, Issue 11 (2017)

Kinetics and mechanism of complexation of Cu (II) with γ-L-glutamyl-L-cyteinylglycine

Author(s):
Yogeshwar Sharma
Abstract:
The kinetics of the complexation of Cu(II) with γ-L-glutamyl-L-cyteinylglycine (IUPAC name: (2S)-2-Amino-4-{[(1R)-1-[(carboxymethyl)carbamoyl]-2-sulfanylethyl]carbamoyl}butanoic acid) has been investigated at 25, 30, 35 and 40± 0.05 °C in the pH range 2.51-3.53 using Aminco Morrow Stopped Flow Spectrophotometer. The ionic strength was maintained at 0.1 M KNO3. No indicator was used for this complexation reaction because transmittance changes were large enough to be monitored directly. The anionic form of γ-L-glutamyl-L-cyteinylglycine is more reactive and the protonated form interacts only to a small extent. Kinetic results indicate that the ligand is not involved in the rate determining step which is, in fact, associated with the release of a water molecule from the shell of the metal ions prior to complexation with the ligand. Enthalpy, entropy of activation, energy of the molecule and heat of formation were also calculated. A mechanism consistent with the kinetic data has been suggested.
Pages: 419-427  |  853 Views  356 Downloads
How to cite this article:
Yogeshwar Sharma. Kinetics and mechanism of complexation of Cu (II) with γ-L-glutamyl-L-cyteinylglycine. Pharma Innovation 2017;6(11):419-427.
The Pharma Innovation Journal