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Vol. 6, Issue 11 (2017)

Formulation and evaluation of enteric coated tablet of Senna for the treatment of constipation

Author(s):
Ramchander, Anil Middha and Pawan Jalwal
Abstract:
The plant based herbal formulations has captured the global market of medicines and herbal drugs in raw form now a day’s moved to mainstream by thousands of people for the various health problems, because of the herbal drugs are free from side effects as compare to allopathic drugs available in the market. Therefore the use of traditional system of medicines increasing all over the world and other aspect is the growth of concerned pharmaceutical companies due to increasing the research process for the better quality, safety and efficacy. Senna is the most common stimulant laxatives used as active ingredient. This ingredient has been choice of researchers and ample scientific data is available on the same. Senna is official in various pharmacopoeias and also covered by world health organization (WHO) in its monograph on medicinal plants. Sennosides are the active chemical constituents of senna which is used for the relief of constipation. The pharmacological action of the sennosides is well known which act upon the large intestine and initial convey their action through an interaction with the intestinal bacteria, by which they are hydrolyzed and then reduced to the anthrone the actual active form. The sennosides specifically influence large intestinal motility. Acceleration of colonic transport seems to be a major component of the laxative action. The antraquinone glycosides work by irritating the lining of the upper intestine which incites reflux muscular activity in the colon resulting in bowel motion. Hence senna is considered as powerful laxative used in the treatment of constipation, working through a stimulation of intestinal peristalsis. This supports their pharmacological action in intestine, not in the stomach. Therefore, to make sure the entire quantity of drug is made available to intestine an attempt is made to formulate and evaluate the enteric coated tablet of senna. To achieve the enteric coated formulation Cellulose acetate phthalate was used as enteric coating material in different %age and in vitro release studies of senna tablet was carried out in 0.1 N HCl and Phosphate buffer pH6.8. It was observed during the studies that cellulose acetate Phthalate alone was sufficient to protect the senna tablet in stomach Environment.
Pages: 263-267  |  629 Views  13 Downloads
How to cite this article:
Ramchander, Anil Middha, Pawan Jalwal. Formulation and evaluation of enteric coated tablet of Senna for the treatment of constipation. Pharma Innovation 2017;6(11):263-267.
The Pharma Innovation Journal