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Vol. 6, Issue 11 (2017)

Design, development and evaluation of floating tablet of ranitidine hydrochloride for the treatment of duodenal Ulcer

Author(s):
Pawan Jalwal and Anil Middha
Abstract:
The present study involved the preparation of floating tablet of ranitidine. The tablets were prepared with both direct compression and wet granulation methods. It was found that wet granulation method facilitated greater efficiency in controlling ranitidine release. Hence, all further formulations were prepared with wet granulation technique. We prepared 11 batches (R01-R11). (R01) was prepared by direct compression but it was failed because it was not compressed so this batch failed. Ranitidine hydrochloride is also a H2-receptor antagonist. It is degraded in the gastric acid. Floating dosage form is the best alternate to increase the bioavailability. It has a furan ring. It has melting point 69-70 ˚C. The wavelength of ranitidine is at 229 nm and 315 nm (water used as medium).
Pages: 239-244  |  944 Views  9 Downloads


The Pharma Innovation Journal
How to cite this article:
Pawan Jalwal, Anil Middha. Design, development and evaluation of floating tablet of ranitidine hydrochloride for the treatment of duodenal Ulcer. Pharma Innovation 2017;6(11):239-244.
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