Synthetic steroids containing a tertiary butyl group and their biological activities
Tatyana A Gloriozova, Vladimir V Poroikov and Valery M Dembitsky
The present review article describes biological activities of synthetic steroids containing a tertiary butyl group. More than 25 biological active steroids have shown confirmed antitumor, antiviral, or apoptosis, and other activities. The structures, reported and predicted activities of a selection of describes steroids are reported. With the computer program PASS based on structure–activity relationships (SAR) some additional activities are also predicted, which point toward new possible applications of these lipids. This article emphasizes the role of steroids containing a tertiary butyl group as an important source of leads for drug discovery.
How to cite this article:
Tatyana A Gloriozova, Vladimir V Poroikov, Valery M Dembitsky. Synthetic steroids containing a tertiary butyl group and their biological activities. Pharma Innovation 2017;6(11):84-92.