Vol. 6, Issue 10 (2017)

Author(s):
Bharat W Tekade, Umesh T Jadhao, Vicky R Vig and Vijay R Patil

Abstract:
The present research investigation carried out was aimed to develop colon drug delivery system using Natural gum of Boswellia serrata. Physicochemical properties of gum were studied like micrometrics properties, pH and viscosity. The matrix tablets were prepared by direct compression technique using Diclofenac sodium as a model drug and various concentration of the drug and polymer was used to choose the suitable concentration of gum to be used with drug for the colonic drug delivery. The prepared tablets were evaluated for weight variation, hardness, thickness, friability, % drug content, disintegration time, in vitro drug release. % Drug release was found as F1- 97.56 ± 0.13 % in 22hrs, F2-95.21 ± 0.01% in 22hrs, F3-94.82 ± 0.01 % in 23 hrs, F4-92.36 ± 0.12 % in 24hrs, F5-90.22 ± 0.16 % in 24hrs, F4 showed good result overall as compared to others. Stability study was carried out for optimized batch (F4) By exposing it to temperature 40°C ± 0.21°C and 75% ± 0.16% RH for 60 days.