Vol. 6, Issue 10 (2017)

Author(s):
S Shirisha, Avula Naveen, K Indira and P Vijaykrishna

Abstract:
Objectives: To evaluate the antidiabetic and Hypolipidaemic effect of Gymnema sylvestre in comparison with Glibenclamide in alloxan induced diabetic Rabbits. Materials and method: Rabbits were randomly divided into 3 groups, each comprising 6 rabbits. Group 1 - Normal control distilled water, Group 2 - Test drug Gymnema sylvestre extract - 800mg/kg, Group 3 - Standard drug Glibenclamide - 0.5mg/kg was administered orally for 30 days. The fasting blood glucose and serum lipid profile were estimated in both normal and alloxan induced diabetic rabbits. Results: The percentage reduction in FBS after 30days of treatment in Gymnema sylvestre group 69.91% and in Glibenclamide group 65.75%, difference between groups was statistically significant. P value - 0.0139**. The percentage reduction in lipid levels after 30days of treatment in Gymnema sylvestre group were TG-30%; TC-38%; HDL-12.30%;LDL-78.78% and in Glibenclamide group were TG-9.6%;TC-30%; HDL-4%; LDL-45%. There was statistically significant difference between groups in TG, TC, HDL except LDL. P value TG (0.002**), TC (0.02*), HDL (0.0004***), LDL (0.067). Conclusion:The leaf extract of Gymnema sylvestre showed excellent antidiabetic potential and equally effective when compared with Glibenclamide in alloxan induced diabetic rabbits. Hypolipidemic effect of Gymnema sylvestre should be further evaluated in comparison with standard hypolipidemic drugs.