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- E-ISSN Number: 2277-7695
- P-ISSN Number: 2349-8242
- CODEN Code: PIHNBQ
- ZDB-Number: 2663038-2
- IC Journal ID: 7725
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Vol. 6, Issue 1 (2017)
Design and optimization of In-situ floating gel containing ondansetron hydrochloride dihydrate using 32 factorial design
Author(s):
Shelke Gajanan, Dhobale Shankar, Jadhav Suresh and Gaikwad Dushyant
Shelke Gajanan, Dhobale Shankar, Jadhav Suresh and Gaikwad Dushyant
Abstract:
The aim of the present study was to develop an in-situ floating gel of Ondansetron HCl dihydrate. The Ondansetron HCl dihydrate has low gastro intestinal Transit time that result in low absorption of drug. Floating in-situ gel is most suitable form to achieve greater absorption of drug. In-situ gel floats on the gastric fluid for sufficient time and also increases the gastric transit time. An in-situ floating gel prepared by using various excipients like sodium alginate, calcium carbonate, sodium citrate, D-mannitol, methyl paraben, propyl paraben. The compatibility study was performed by using FT-IR. Formulations were optimized by using 32-factorial designs. Concentration of Sodium Alginate and calcium carbonate were selected as independent variables whereas floating lag time and drug release after 8 hrs (Q8) were selected as dependent variables. The prepared formulations were evaluated for viscosity, floating lag time, duration of floating, in- vitro gelation and in-vitro drug release. All formulations showed floating within 60 s and had total floating time 24 hrs.
The aim of the present study was to develop an in-situ floating gel of Ondansetron HCl dihydrate. The Ondansetron HCl dihydrate has low gastro intestinal Transit time that result in low absorption of drug. Floating in-situ gel is most suitable form to achieve greater absorption of drug. In-situ gel floats on the gastric fluid for sufficient time and also increases the gastric transit time. An in-situ floating gel prepared by using various excipients like sodium alginate, calcium carbonate, sodium citrate, D-mannitol, methyl paraben, propyl paraben. The compatibility study was performed by using FT-IR. Formulations were optimized by using 32-factorial designs. Concentration of Sodium Alginate and calcium carbonate were selected as independent variables whereas floating lag time and drug release after 8 hrs (Q8) were selected as dependent variables. The prepared formulations were evaluated for viscosity, floating lag time, duration of floating, in- vitro gelation and in-vitro drug release. All formulations showed floating within 60 s and had total floating time 24 hrs.
The concentration of Sodium Alginate and calcium carbonate had significant influence on floating lag time, cumulative percentage drug release in 8 hrs. Among different formulae tested, formulation A5 showed optimum floating lag time (38sec) and drug release after 8 hrs (98.56%). Therefore, floating in- situ gelling of Ondansetron HCl dihydrate containing Sodium Alginate as a gelling polymer to sustain the drug release for 8 hrs. All the formulations showed good pourability.
Pages: 83-88 | 1734 Views 220 Downloads
How to cite this article:
Shelke Gajanan, Dhobale Shankar, Jadhav Suresh, Gaikwad Dushyant. Design and optimization of In-situ floating gel containing ondansetron hydrochloride dihydrate using 32 factorial design. Pharma Innovation 2017;6(1):83-88.
Journal code(s)
- E-ISSN Number: 2277-7695
- P-ISSN Number: 2349-8242
- CODEN Code: PIHNBQ
- ZDB-Number: 2663038-2
- IC Journal ID: 7725
Main Menu
Special Issue
Copyright Form
Identifier
The Pharma Innovation Journal
