Vol. 6, Issue 1 (2017)
The intraocular pressure (I.O.P) lowering effects of investigational anti-glaucoma drugs often need comparison with existing drugs in rabbits
Sampath D, Kudagi BL, Haritha M, Rajesh Kumar M, Sharanya M, Ahmed SK, Bhopal Chandra V and Anjani Devi N
Glaucoma is defined as heterogeneous group of disorders which manifests as chronic progressive optic neuropathy, characterized by specific morphological changes to the optic nerve head & retinal nerve fiber layer, with resultant loss of retinal ganglion cells, which results in loss of visual fields. Glaucoma is the leading cause of irreversible blindness worldwide & is second only to cataract as the most common cause of blindness over all. This study was designed to establish baseline information of the intraocular pressure lowering effect of three currently using anti - glaucoma drugs, which belongs to three different groups, so that they acts as a benchmark for the efficacy evaluation of the future anti - glaucoma drugs. The experiment was carried out in Glaucoma induced rabbits (Water -loaded Rabbit Model), drugs were administered in the form of eyedrops, there is decrease in I.O.P, 3.2 mmHg, 4.6 mmHg & 6.6 mmHg with timolol (0.05%), brimonidine (0.2%), & latanoprost (0.005%) respectively, showed significant (p<0.0001) decrease in the intraocular pressure. Latanoprost showed more efficacy than brimonidine and timolol in rabbits. Brimonidine has more effective than that of Timolol and less effective as compared to latanoprost.
How to cite this article:
Sampath D, Kudagi BL, Haritha M, Rajesh Kumar M, Sharanya M, Ahmed SK, Bhopal Chandra V, Anjani Devi N. The intraocular pressure (I.O.P) lowering effects of investigational anti-glaucoma drugs often need comparison with existing drugs in rabbits. Pharma Innovation 2017;6(1):10-15.