Development and In Vitro evaluation of buccoadhesive tablets of losartan potassium
Sireesha Attuluri, P Prem Kumar, Venkatesh Murukutla and Manohar Babu S
The aim of the present study was to design buccoadhesive bilayered tablets to release the drug unidirectionally in buccal cavity for extended period of time in order to avoid first-pass metabolism for improvement in bioavailability, to reduce the dosing frequency and to improve patient compliance. An attempt has been made to develop buccoadhesive bilayered tablets comprising of drug containing bioadhesive layer and drug free backing layer to release the drug for extended period of time with reduction in dosing frequency. Tablets of Losartan potassium were prepared by direct compression method using bioadhesive polymers like Carbopol 934P, Methocel K4M, Methocel K15M and sodium carboxy methyl cellulose either alone or in combinations with backing layer of ethyl cellulose. Slow, controlled and complete release of Losartan potassium over a period of 12 hours was obtained from matrix tablets formulated employing HPMC K4M and Carbopol 934P. This tablets exhibited good buccoadhesion time for over 12 hours. Good oral controlled released bilayered buccoadhesive tablet formulation of Losartan potassium could be developed using HPMC K4M and Carbopol 934P. Drug release could be obtained upto 10 hrs with a polymer combination of Carbopol 934P and HPMC K4M in the ratio of 1:1 i.e. formulation F2.
How to cite this article:
Sireesha Attuluri, P Prem Kumar, Venkatesh Murukutla, Manohar Babu S. Development and In Vitro evaluation of buccoadhesive tablets of losartan potassium. Pharma Innovation 2016;5(9):90-95.