Abstract:A lot of papers are related to the study of the state of immune response in patients with chronic obstructive pulmonary disease (COPD), however, we are of the opinion that the development of immune alterations in this pathology is not fully disclosed, particularly at the level of functional activity of macrophages, subpopulations of peripheral blood lymphocytes and their synthesis of a range of inflammatory transmitters and thus globalization of systemic symptoms of the pathology at the level of the whole human body.
The paper presents data on pathogenetic peculiarities of immune response in the process of generation of COPD stage III in the exacerbation phase. The obtained results show significant role of lymphocytic subpopulations of lymphocytes in the formation of both, local manifestations and systemic effects of COPD.