Changes of daily profile of blood pressure with application of alpha-lipoic acid and zinc sulfate in patients with type 2 diabetes mellitus who have had myocardial infarction
NV Altunina, VG Lizogub and AN Bondarchuk
The article presents the dynamics of parameters of 24-hour ambulatory blood pressure monitoring of 49 postinfarction patients with type 2 diabetes mellitus (DM) under the influence of 4-month combined treatment of alpha-lipoic acid (ALA) with zinc (Zn) sulfate. Treatment showed a significant decreasing in systolic BP (SBP) and diastolic BP (DBP) morning rise (р<0, 05) and mean daily and nighttime DBP variability (р<0, 05). Besides, it is recorded a positive downward trend in the level of mean daily and night-time SBP and DBP, mean daytime DBP, SBP variability in all time intervals and the DBP daytime variability. After the applied treatment it was the redistribution of patients by type of BP daily profile with the decrease of the contribution of “night-peakers” – 12, 2% on SBP and 14, 3% on DBP. Thus, the 4-month use of ALA and Zn sulfate in the complex treatment of patients with type 2 DM who had myocardial infarction, causes a decrease in BP morning rise, daily and nighttime DBP variability and improves daily profiles of SBP and DBP.
How to cite this article:
NV Altunina, VG Lizogub, AN Bondarchuk. Changes of daily profile of blood pressure with application of alpha-lipoic acid and zinc sulfate in patients with type 2 diabetes mellitus who have had myocardial infarction. Pharma Innovation 2016;5(9):08-12.