Vol. 5, Issue 8 (2016)

Author(s):
Muhammed A AL-Diwan, Zainab A AL-Wahhap and Wasfi A AL-Masoudi

Abstract:
The present study was aimed to investigate the potential effect of crude extract of Brassica juncea L. seeds in alleviating hematological and serum biochemical alterations induced by cadmium chloride toxicity in rats. For this purpose, 32 adult male rats were selected and divided in to 4 groups (8 rats for each group), Group (1): received distilled water by i.p injection and served as a control, Group (2) was daily administered with mustard oil at a dose of 112 mg/Kg B.W orally, Group (3) was daily administered with cadmium chloride at a dose of 225 mg/Kg B.W by i.p injection and Group (4) was daily administered with cadmium chloride at a dose of 225 mg/Kg B.W by i.p injection and after one hour of cadmium chloride administration, the treated rats were given with the mustard oil extract at a dose of 112 mg/Kg B.W. The obtained results of the present research indicated that the cadmium chloride possesses a deleterious effect on blood cytology, induce oxidative damage, hepatic-renal dysfunction, increase of MDA and thyroid hormone defect. The administration of mustard oil with cadmium chloride minimized the hazard effects of cadmium chloride. It improved the RBCs count, PCV, Hb concentration, total & differential WBCs count and blood indices, and diminished the level of serum malondialdehyde (MDA). Moreover, it ameliorates the activities of AST, ALT, ALP, cholesterol, TG, LDL, VLDL, HDL, urea, creatinine, glucose and various thyroid hormones like TSH, T4 and T3.