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Vol. 5, Issue 8 (2016)

An optimization study of rifampicin oral suspension formulation using central composite design of experiment model

Author(s):
SA Kale and VH Bajaj
Abstract:
In the present study, an optimization design of experiments was applied in evaluation of oral suspension formulation of Rifampicin. Rifampicin is a widely used antibiotic to treat a several types of bacterial infections like tuberculosis, leprosy, and Legionnaire's disease. Central Composite Design optimization design was used to study main and interaction effect of variables affecting CQAs. Impact of formulation and manufacturing process variables like hydrocolloid (%) and homogenization speed (rpm) was studied on critical quality attributes (CQAs) of Rifampicin oral suspension. Viscosity (cps) and content uniformity (% C.V.) were identified as CQAs of Rifampicin oral suspension.
Pages: 11-17  |  2161 Views  379 Downloads


The Pharma Innovation Journal
How to cite this article:
SA Kale, VH Bajaj. An optimization study of rifampicin oral suspension formulation using central composite design of experiment model. Pharma Innovation 2016;5(8):11-17.

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