Vol. 5, Issue 8 (2016)

Author(s):
Mohammad Waseem, Shruti Jain, Suhel Parvez and Mohd. Akram

Abstract:
Pesticides may provoke oxidative stress leading to produce free radicals and alternate antioxidant or oxygen free radical scavenging enzyme system. Imidacloprid (Imd) is a systemic insecticide and act as a toxic substance frequently utilized into combat insects, rodents and plants pests and other creatures that can pose agricultural problems. Oxidative stress has been proven to be involved in Imd-induced toxicity including neurotoxicity and hepatotoxicity. The aim of current study was to explore the dose dependent damage caused by Imd on liver and brain under in vitro conditions. The study was also planned to assess neuroprotective and hepatoprotective actions of Ascorbic acid (AsA) on Imd induced oxidative stress in liver and brain of swiss albino mice as an in vivo model. Oxidative stress machinery were evaluated against hepatotoxicity and neurotoxicity induced by Imd. AsA modulated altered non-enzymatic machinery in liver and brain of swiss albino mice. AsA was found to be more effective in ameliorating mice against Imd-induced oxidative stress by enhancing antioxidant defense mechanisms.