Vol. 5, Issue 7 (2016)

Author(s):
Mathew George, Lincy Josepha and Minu Mathew

Abstract:
In the present study, we examined the learning and memory effect of whole plant of Tinospora cordifolia. Dried and powdered whole plant of Tinospora cordifolia was extracted with hydro alcohol by soxhlet extraction method and the influence of plant extract on spatial recognition memory was studied using Y-maze. Spatial memory was measured by the total number of entries and duration spent in each arm of the Y-maze following administration of the extract with the reference to a standard. Transfer latency (TL) in the Ymaze was expressed as inflexion ratio (IR). The number of arm visits during the first trial and second trial period were measured as an index of locomotor activity. Diazepam (100mg/kg) was used to induce amnesia in animals. The results indicated that after 24 h, the plant extract shown significant reduction in transfer latency when compared to the reference standard.