Design, Development and Evaluation of Solid Dispersion incorporated Transdermal Gel of Benzoyl Peroxide
Jitender Mor, Rajinder Mann, Bharti Chopra
In recent years, the development of transdermal dosage form designed to have systemic effects has been attracting increasing attention, due to the several advantages that this administration route offers, such as a better control of blood levels, a reduced incidence of systemic toxicity, an absence of hepatic first-pass metabolism etc. Among the topical formulations, clear transparent gels have widely accepted in both cosmetics and pharmaceuticals. Gels have gained more and more importance because the gel-bases formulations are better percutaneously absorbed than creams and ointment bases. Most topical gels are prepared with organic polymers, such as carbomers, that impart an aesthetically pleasing, clear, sparkling appearance to the product, and are easily washed off the skin with water. In addition, many gels contain penetration enhancers, such as alcohol, in the formulation. Benzoyl Peroxide (BPO) is a first-line topical treatment in acne vulgaris. BPO is an old and established treatment agent with keratolytic and antibacterial action. The major drawback of BPO is its poor aqueous solubility. Solid dispersion is an effective technique which can easily enhance the dissolution rate of drugs. This technique involves one or more hydrophobic drugs in an inert hydrophilic carrier or hydrophilic matrix at solid state. Solid dispersion also helps to improve its skin irritation side effect. Solid dispersion of Benzoyl Peroxide using β-cyclodextrin, PEG 6000 as a carrier is prepared and evaluated for various parameters such as % practical yield, drug content, In-vitro diffusion study, measurement of pH, Viscosity study, Homogeneity.
How to cite this article:
Jitender Mor, Rajinder Mann, Bharti Chopra. Design, Development and Evaluation of Solid Dispersion incorporated Transdermal Gel of Benzoyl Peroxide. Pharma Innovation 2016;5(7):13-18.