Vol. 5, Issue 7 (2016)

Author(s):
Jitender Mor, Deepa Batra, Savita Ahlawat

Abstract:
The term solid dispersion refers to a group of the solid products consisting of at least two different components, generally a hydrophilic matrix and a hydrophobic drug and matrix can be either crystalline or amorphous. The drug can be dispersed molecularly, in amorphous particles or in crystalline particles. Solid dispersion technologies are particularly promising for improving the aqueous solubility, dissolution rate and bioavailability of BCS Class II drugs as bioavailability of drugs depends on their solubility and permeability. The main objective of the present work was to evaluate the feasibility of the melt granulation technique to improve the dissolution characteristics of a poorly water soluble drug, Glibenclamide. Glibenclamide was chosen as a water-insoluble model drug. Conjugation of Glibenclamide with the different types of carriers was used to increase its Solubility and dissolution rate. Formulation of granules was done by physical mixture and melt granulation technique. The drug carrier interactions were studied by IR spectral analysis. Granules were evaluated by Bulk density, Tapped density, Carr’s index, Hausner ratio and Angle of repose. In-vitro dissolution studies were done on solid dispersion formulations.