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Vol. 5, Issue 6 (2016)

Formulation development & in vitro evaluation of immediate release tablets of Nevirapine cyclodextrin complexes

P Venkateswara Rao and Prasanna Kumar Desu
Nevirapine is an Anti-retro viral agent using in the management of HIV diseases. It is very slightly soluble in water. In the present study attempt has been made to prepare and characterize inclusion complex of Nevirapine with β-Cyclodextrin. The phase solubility analysis indicated he formation of 1:1 molar inclusion complex of Nevirapine with β-CD. Apparent stability constant (Kc) was found o be 164.557 M-1. The inclusion complexes prepared by different methods viz. Physical mixture and Solvent evaporation methods. The prepared complexes were characterized using FT-IR. Further, the inclusion complexes containing Nevirapine: β-Cyclodextrin (1:2) was formulated into immediate release tablets which are stable and enhancing in solubility and faster dissolution. For the development of Nevirapine tablets, the excipients selected were Starlac as diluents, Croscarmellose sodium and Sodium Starch Glycolate as super disintegrants, Microcrystalline cellulose (MCC) as binding agents, Aerosil as glidant, Magnesium Stearate as lubricant. The formulation blend was evaluated for Precompression studies and compressed tablets were evaluated for post compression studies and the results were found to be within the limits. The compatibility studies were performed which resulted in no interactions between drug and excipients.
Pages: 110-114  |  1324 Views  30 Downloads

The Pharma Innovation Journal
How to cite this article:
P Venkateswara Rao, Prasanna Kumar Desu. Formulation development & in vitro evaluation of immediate release tablets of Nevirapine cyclodextrin complexes. Pharma Innovation 2016;5(6):110-114.
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