Immunomodulation is a process, which alters the immune system of an organism by interfering with its functions. This interference results in either immunostimulation or immunosuppression. An immunomodulator is a substance that helps to regulate the immune system. Keeping in this view, efforts have to be directed to modulate the immune responses, to permit effective treatment of various ailments associated with immune system and thus the development of a safe and effective immunomodulator for clinical use.
Methods: Sonerila tinnevelliensis Fischer an ethnomedicinal plant was studied for its immunomodulatory activity. Immunomodulatory activity of different doses of ethanol extract of S. tinnevelliensis was evaluated in Swiss albino mice. Mice were treated with two doses (200 and 400mg/kg body weight) for 5 days. Body weight, relative organ weight, delayed type hypersensitivity (DTH) response and Haemagglutinin titre (HT) were studied in various groups of animals.
Results: The results obtained show a significant increase (p<0.05) in body weight and relative organ weight of spleen, liver and kidney at dose of 400mg/kg. The S. tinnevelliensis extract eliciated a significant increase (p<0.05) in the DTH response at dose of 400mg/kg. In the HT test, the plant extract showed a stimulatory effect at all doses. The dose of 400mg/kg significantly (p<0.05) increases the WBC count, compared with the control group
Conclusions: Overall, S. tinnevelliensis showed a stimulatory effect on both humoral and cellular immune functions in animal models.