Vol. 5, Issue 4 (2016)
Morphometric characteristic of the pancreatic islets in the treatment of experimental diabetes with insulin
Morphometric parameters of pancreatic islets of Wistar male rats were studied during treatment of experimental diabetes mellitus (EDM) with insulin. For this diabetes was simulated by intraperitoneal Streptozotocin administration. Starting with the 14-th day of diabetes development, every day animals were injected subcutaneously Insulin glargine("Lantus"). Material sampling was performed during the 42-nd, the 56-th and the 70-ieth day of the experiment. Correction associated with EDM with insulin in animals a mild reduction of lymphocytic infiltration, a slight decrease in intracellular edema of beta and alpha cells were observed. The decrease of glycemia level in fasting and the improvement of the overall health of animals were noted.
How to cite this article:
Olga Ivantsiv. Morphometric characteristic of the pancreatic islets in the treatment of experimental diabetes with insulin. Pharma Innovation 2016;5(4):80-83.