Vol. 5, Issue 4 (2016)

Author(s):
I.R. Romash

Abstract:
The article presents the results of the investigation of changes in endogenous insulin indices and glucose level in blood serum during prolonged treatment (3 months) with atypical antipsychotics. Increase in both indices was observed in the studied groups. The index of endogenous insulin concentration significantly increased by 10.9% and constituted 17.56±0.70 uIU/mL (p<0.05) and glucose level in blood serum increased by 36.6% and amounted 7.01±0.29 mmol/L (p<0.05). Long-term risperidone use caused significant increase in insulin concentration by 19.3% up to the level of 19.85±1.50 uIU/mL (p<0.05) and increase in fasting glycemia by 34.5% reaching 8.44±0.23 mmol/L (p<0.05). Treatment with quetiron during 3 months caused a significant increase in insulin concentration in blood serum by 2.96% from 15.05±1.73 uIU/mL to 15.49±0.69 uIU/mL (p<0.05) as well as a significant increase in glycemia level by 20.3% from 5.39±0.78 to 6.76±0.27 mmol/L (p<0.05).