Solid as solvent- Novel spectrophotometric quantitative analysis of ornidazole tablets using solids (Eutectic liquid of phenol and lignocaine hydrochloride) as solubilizing agents (Mixed solvency concept)
RK Maheshwari, Lovkush Pandey, Akash P Shah, Shivam Prasad Tiwari
The pollution and toxicity caused by most of the organic solvents is a big challenge. The researchers are doing much work to give eco-friendly solutions for this challenge. The present investigation is an attempt to show that solids can also be wisely used to act as solvent precluding the use of organic solvents. The main objective of the present study is to demonstrate the solvent action of solids. In the present study, a eutectic liquid (PL-41) obtained by triturating phenol crystals and lignocaine hydrochloride in 4:1 ratio on weight basis was employed to extract (dissolve) ornidazole drug from fine powder of its tablets. Distilled water was used for dilution to carry out spectrophotometric estimation at 319 nm without the help of organic solvent. The solubility of ornidazole in distilled water at room temperature was found to be 8.03mg/ml. The solubility of the same drug in PL-41was more than 150 mg per ml (of PL-41). Proposed spectrophotometric analytical method is novel, rapid, free from toxicity of organic solvent, accurate and reproducible. Recovery studies and statistical data proved the accuracy, reproducibility and precision of the proposed method. The presence of tablet excipients, phenol and lignocaine hydrochloride did not interfere in the spectrophotometric estimation at 319 nm. Phenol does not interfere above 300 nm and lignocaine hydrochloride does not interfere above 310 nm.
How to cite this article:
RK Maheshwari, Lovkush Pandey, Akash P Shah, Shivam Prasad Tiwari. Solid as solvent- Novel spectrophotometric quantitative analysis of ornidazole tablets using solids (Eutectic liquid of phenol and lignocaine hydrochloride) as solubilizing agents (Mixed solvency concept). Pharma Innovation 2016;5(3):26-27.