Deciphering the code of 'Cure' in the era of HIV/AIDS
Dr. Matin Ahmad Khan, Dr. Ramji Lal Agarwal, Dr. Sunil Kumar Verma, Dr. Uma Shankar Singh, Dr. Shubhashish Sircar, Dr. Vinod Kumar, Dr. Asish Kumar Biswas, Dr. J Srinivas Rao, Dr. (Ms) Shashi Bala Nag, Dr. Nirmal Drolia, Dr. Indrajeet Kumar
A cure for HIV has always been the holy grail of HIV research though ‘Cure do have philosophical, and programmatic connotations in the context of HIV/AIDS. Many developments and strategies have been evolved to tame this virus, since its reporting - some 32 years ago. Medical fraternity is reacting with guarded appreciation and anticipation, more so after the publication of reports of Sterilizing /functional cure of a man (known as Berlin patient’) following BMT from a donor having deficient chemo co receptor CCR5 (vital for HIV entry) gene and one baby, known as ‘Mississippi Baby’ who was infected with HIV at birth but is now apparently free of the virus. through a hit hard, hit early approach taken by researchers and doctors in relation to antiretroviral therapy These findings hold out the hope that treatment during acute HIV infection (ala –Mississippi baby ) has the potential to transform the outcome of HIV infection in at least some individuals. The use of early and aggressive treatment could be a paradigm shift in HIV/AIDS treatment in children in the developing world, where mothers are typically treated during pregnancy to lower the risk of passing the virus on to the child. Both long-term survivors and those who have been exposed to HIV but remain sero negative (called Elite Controllers and Slow/Non Progressors) offer a great opportunity to study the mechanisms of resistance to HIV infection and disease. Till ‘Cure’ is not achieved we will have to remain steadfast in working towards it.
How to cite this article:
Dr. Matin Ahmad Khan, Dr. Ramji Lal Agarwal, Dr. Sunil Kumar Verma, Dr. Uma Shankar Singh, Dr. Shubhashish Sircar, Dr. Vinod Kumar, Dr. Asish Kumar Biswas, Dr. J Srinivas Rao, Dr. (Ms) Shashi Bala Nag, Dr. Nirmal Drolia, Dr. Indrajeet Kumar. Deciphering the code of 'Cure' in the era of HIV/AIDS. Pharma Innovation 2016;5(2):15-21.