Vol. 5, Issue 1 (2016)
Effect of L-arginine on blood pressure profile and bronchial patency in patients with hypertension burdened by pulmonary hypertension of bronchopulmonary origin
Luybov Dron,Iryna Kupnovytska
The article deals with the problem of peripheral hemodynamics correction in the systemic and pulmonary circulation, circadian profiles of blood pressure and respiratory ventilation in patients with stage 2 hypertension, burdened by obstructive pulmonary disease, with the use of L-arginine – exogenous source of nitric oxide. Material and methods of investigation: This study investigated 100 patients with stage 2 hypertension (2nd- and 3rd-degree) including 80 patients with hypertension, burdened by stage 2 pulmonary hypertension of bronchopulmonary origin, and 20 patients with essential hypertension of the identical stage and degree at the age of 56.5±4.12. Results: It has been observed that chronic obstructive disease burdens the course of hypertension by peripheral hemodynamics deterioration and systolic pressure increase in the pulmonary circulation leading to heart remodeling. A number of positive effects of L-arginine on the course of the cardiovascular and respiratory systems comorbide pathology have been established. Conclusions: L-arginine, used in combination therapy in patients with hypertension accompanied by chronic obstructive disease, induces antihypertensive therapy potentiation, bronchial patency improvement, and circadian profiles of blood pressure resetting.
How to cite this article:
Luybov Dron,Iryna Kupnovytska. Effect of L-arginine on blood pressure profile and bronchial patency in patients with hypertension burdened by pulmonary hypertension of bronchopulmonary origin. Pharma Innovation 2016;5(1):65-68.