Vol. 5, Issue 1 (2016)

Author(s):
Balvinder Singh, Pawan Jalwal, Jyoti Dahiya, Sonia Khokhara

Abstract:
One out of thirteen people are suffering from Anxiety disorders. So many drugs are available in market. But none of the drug is said to be safe. This lack of safety gives scope of future trials of newer anxiolytic drugs. This review focuses on the various Research Methods for studying the anxiolytic effect of drugs. The various methods are divided into two parts - Conditioned responses and Unconditioned responses. Under Conditioned responses, various methods are- Geller–Seifter conflict (GS), Vogel conflict, Fourplate test (FPT), Conditioned emotional response (CER), Conditioned taste aversion (CTA), Fearpotentiated startle, Defensive burying, Active/passive avoidance. Under Unconditioned responses, various methods are - Elevated plus maze (zero/T maze), Light/dark exploration (L/D), Social interaction, Open field, Ultrasonic vocalization (pain or separation), Fear/anxiety-defence test batteries, Staircase test, Holeboard and Predator.