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Vol. 4, Issue 9 (2015)

Randomized controlled clinical comparative study of isobaric ropivacaine 0.75% (22.5mg) versus isobaric bupivacaine 0.5% (15mg) in intrathecal Anaesthesia

Author(s):
Dr. VK Dhulkhed, Dr. SV Nike and Dr. PB Patil
Abstract:
Aim: To assess, subjectively as well as objectively whether ropivacaine 0.75% (22.5 mg) can replace bupivacaine 0.5% (15 mg) as a long acting local anaesthetic agent in patients undergoing lower abdominal surgery under intrathecal anaesthesia.
Material and method: Hemoglobin, Packed Cell volume, Bleeding time, Clotting time, Renal function test Blood sugar, Liver function test, ECG, Chest x-ray and platelet count were done. Patients who satisfied the inclusion criteria were explained about the nature of the study and the anesthetic procedure. Written informed consent was obtained from all patients included in the study. In the Operation theatre appropriate equipment for airway management and emergency drugs were kept ready. Patient was shifted from the premedication room to Operation theatre. The horizontal position of the operating table was checked and the patient was placed on it.
Result: The mean duration of segmental height (Thoracic segment) of pain and temperature in group “R” was 10.2 ± 1.85 and for group “B” was 7.98 ± 1.523. By using 2 independent sample t-tests, P-value was 0.00. Since the P-value is <0.05, there is significant difference between onset of loss of sensation to pain and temperature in group “R” and group “B”. The mean duration of segmental height (Thoracic segment) of touch and pressure in group “R” was 7.92 ± 1.98 and for group “B” was 5.60 ± 1.34. By using 2 independent sample t-tests P-value was 0.00. Since the P-value is <0.05, there is significant difference between segmental height (Thoracic segment) in touch and pressure in group “R” and group “B”. Conclusion: Bupivacaine has higher cephaled spread and longer duration of sensory analgesia than ropivacaine. The duration of motor blockade was similar with the two drugs
Pages: 86-89  |  549 Views  74 Downloads


The Pharma Innovation Journal
How to cite this article:
Dr. VK Dhulkhed, Dr. SV Nike, Dr. PB Patil. Randomized controlled clinical comparative study of isobaric ropivacaine 0.75% (22.5mg) versus isobaric bupivacaine 0.5% (15mg) in intrathecal Anaesthesia. Pharma Innovation 2015;4(9):86-89.

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