Vol. 4, Issue 8 (2015)

Result: The effects of CBZ (5 to 20 mg/kg), APO (1.5 and 3 mg/kg) and DAM (5 and 10 mg/kg) treatment on the cataleptic effect of HAL (1 and 1.5 mg/kg) were studied and compared. CBZ at 5, 10 and 20 mg/kg doses was significantly less effective than 1.5 and 3 mg/kg APO and 5 and 10 mg/kg DAM in antagonizing the cataleptic effect of 1 and 1.5 mg/kg HAL. Our results indicate that CBZ, on weight basis, is significantly less effective than APO and DAM in exerting the anticataleptic effect.

Conclusion: CBZ indicate that there is a functional interaction between the corticoglutamatergic neurons and the nigrostriatal DAergic neurons. Further, our results lend support to the reports cited in literature stating that the corticoglutamatergic neurons exert an inhibitory influence on the nigrostriatal DA ergic neurons indirectly by releasing GABA from the intrinsic striatal GAB Aergic interneurons, the striatonigral GABAergic neurons and the GABAergic neurons located in the SNc.