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Vol. 4, Issue 7 (2015)

Comparison of antioxidant property of two antihypertensive drugs amlodipine and Telmisartan in patients of essential Hypertension

Author(s):
Dr. Anup Hajare and Dr. Promode B Aket
Abstract:
Aim: Evaluate the relation of oxidative stress and hypertension and also to evaluate the antioxidant property of two commonly used antihypertensive drugs.
Material and Method: This was an open labeled, comparative, prospective, interventional study involving 30 human patients and 15 human healthy volunteers selected from the outpatient Department of Medicine, Krishna.
Result: ANOVA application to the values of all three groups gave P value of 0.5438 which was also >0.05 and it was not significant. Considering all three parameters we can say that there is no difference among all three groups in the level of oxidative stress before starting treatment.
Conclusion: There is increase in the activity of SOD activity after treatment with Telmisartan for 3 months. There is not much difference in SOD increasing property of Amlodipine and Telmisartan. Both antihypertensive drugs amlodipine and telmisartan are having antioxidant property at least by means of increasing SOD (antioxidant enzyme) activity. But neither of them is better than the other at this.
Pages: 142-144  |  509 Views  78 Downloads


The Pharma Innovation Journal
How to cite this article:
Dr. Anup Hajare, Dr. Promode B Aket. Comparison of antioxidant property of two antihypertensive drugs amlodipine and Telmisartan in patients of essential Hypertension. Pharma Innovation 2015;4(7):142-144.

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