Vol. 4, Issue 7 (2015)

Material and Method: This was an open labeled, comparative, prospective, interventional study involving 30 human patients and 15 human healthy volunteers selected from the outpatient Department of Medicine, Krishna.

Result: ANOVA application to the values of all three groups gave P value of 0.5438 which was also >0.05 and it was not significant. Considering all three parameters we can say that there is no difference among all three groups in the level of oxidative stress before starting treatment.

Conclusion: There is increase in the activity of SOD activity after treatment with Telmisartan for 3 months. There is not much difference in SOD increasing property of Amlodipine and Telmisartan. Both antihypertensive drugs amlodipine and telmisartan are having antioxidant property at least by means of increasing SOD (antioxidant enzyme) activity. But neither of them is better than the other at this.