Vol. 4, Issue 7 (2015)

Material and Method: One of the group received serratiopeptidase and diclofenac the 2nd group received Diclofenac only patients and the 3rd group did not receive any medication. The study enrolled 60 patients with confirmed osteoarthritis of knee and 60 surgical post operative patients. A total of 120 patients. Efficacy parameters consisted of WOMAC scores and VAS score for osteoarthritis patients and for Surgery patients it was ASEPSIS scores and VAS scores. They were evaluated on day 0 (before the start of treatment) and day 7 (after the treatment) in Osteoarthritic patient. In surgical postoperative patients it was evaluated on day 0 and day 7 post operatively.

Results: In osteoarthritis patients there was a considerable decrease in WOMAC scores and VAS scores in both groups at the end of 1 week. The decrease in WOMAC scores in Experimental group (Serratiopeptidase + Diclofenac) were comparatively more than the control group (Diclofenac). But was not found statistically significant. In Surgery patients there was a significant decrease in the Asepsis scores and VAS scores in all 3 groups. The decrease in VAS scores were comparatively more in Experimental group and control group when individually compared with No Medication group and was found to be statistically significant. Decrease in VAS scores were comparatively more in control group than in experimental group but was not statistically significant. This showed that healing of the wound was same in all 3 groups while analgesic activity was more in Experimental and control group as compared to No medication group.

Conclusion: It is strongly recommended that only non-steroidal anti-inflammatory drugs should be prescribed for inflammatory conditions till the efficacy of drugs like s serratiopeptidase is proved by large scale, double blind multi-centric, randomised controlled trial.