In-silico Pharmacophore Screening and Structure Based Drug Designing against Migraine Causing Proteins (RAMPs) 1, 2 and 3
Chandan Mishra, Prashant Ankur Jain, Ved Kumar Mishra
Migraine is a chronic neurological disorder characterized by current episodes of several unique throbbing head pain and associated symptoms, such as photophobia. We self understanding of the mechanisms underlying migraine has been hampered by limitations in ascertaining migraine symptoms in animal models. Migraine is a primary headache disorder with almost a genetic basis. Receptor activity-modifying proteins RAMP 1, RAMP 2, and RAMP 3 are unusual accessory proteins that bind with the Calcium gene-related peptide involved in energy homeostasis. Over expression and tension leads to the pain in several parts of the head these proteins are expressed throughout the central nervous system (CNS). The sequence, structure and function of the proteins were deduced by using various bioinformatics tools and databases. Proteins disorder region were identified to reach to the amino acid having a high mutational probability. Binding site was predicted on the basis of repetition of amino acid and proteins were optimized by Sybyl to gain maximum stability. Suitable drug with the respective protein under various parameters of LIPINSKI’s rule was identified. The study provide to the organization as there is no special treatment of the disease and about 10% of adults in worldwide suffer from migraines, according to the World Health Organization.
How to cite this article:
Chandan Mishra, Prashant Ankur Jain, Ved Kumar Mishra. In-silico Pharmacophore Screening and Structure Based Drug Designing against Migraine Causing Proteins (RAMPs) 1, 2 and 3. Pharma Innovation 2015;4(5):28-35.