Vol. 4, Issue 5 (2015)

Author(s):
Abdelmonim Osman Abdelmonim Hamed, Saad Mohamed Hussein Ayoub

Abstract:
The root of Lupinus termis L., a leguminous plant of great potential growing in northern Sudan and native to the Mediterranean basin was investigated phytochemically and assessed for its antimicrobial activity. Previous phytochemical, pharmacological and clinical investigations based on ethnopharmacologic approach recommended the use of the seed ethanolic extract as a safe herbal remedy in treatment programs of shingles. Herein we report the Lupin root oil extracted with petroleum ether from the sweet variety investigated for its lipid profile as well as the quinolizidine alkaloid profile of the root methanolic extract. The GC-MS analysis showed that the oil was composed mainly of oleamide (43.1%); hydrocarbons (26.2%); fatty alcohols (15.8%) and fatty acids (09.58%). The semi-purified alkaloid methanolic extract was composed mainly of lupanine (72%); 13-hydroxylupanine (6.6%); sparteine (4.6%); ammodendrine (3.8%) and 13- Methoxylupanine (2.5%). The two extracts were assessed for their antimicrobial activity and the microorganisms were resistant to the oil extract and were moderately sensitive to the methanolic extract.