Vol. 4, Issue 4 (2015)

Author(s):
Mariana Rymarchuk, Oksana Makarchuk

Abstract:
To determine the correlation of local non-progressive abruption of placenta and the development of placental dysfunction with undifferentiated connective tissue dysplasia (UCTD), we have conducted the case-consequence research with 100 patients. The research included two stages. At the first stage, all the predictors of this complication were divided into 4 groups: somatic anamnesis, obstetric, gynecological and infectious anamnesis, course of the given pregnancy and results of tests for Phase-II detoxification gene polymorphism. At the second stage, all the significant predictors were included in a multifaceted logistic regressive analysis.
The most significant causes of local non-progressive abruption of placenta at placental dysfunction are the following: UCTD (OR-18.86; 6.58-54.02), its visceral markers such as scoliosis (OR-5.76; 2.08-15.97), heart diseases (mitral valve prolapse, hypertensive neurocirculatory dystonia, supplemental chord) (OR-8.61; 3.11-23.83), myopia (OR-6.25; 2.26-17.29), platypodia (OR-4.49; 1.61-12.55), renal diseases (OR-7.94; 2.87-21.98).
The sheer presence of UCTD in this category of patients increases by 18 times the risk of disorder of trophoblast invasion and development of placental dysfunction.