Dynamics of ultrastructural changes exocrine part of rat pancreas under the influence of opioid
P. Popyk, L. Mateshuk-Vatseba
The article is devoted to the study of ultrastructural organization of exocrine part of a white rat pancreas under the conditions of long-term influence of opioid. The paper describes the new data changes in ultrastructure after 2, 4 and 6 weeks of nalbuphine induction. First changes of ultrastructural organization of some exocrine pancreocyte is observed after 2 weeks of nalbuphine induction and grow during next terms of the experiment. Long-lasted influence of opioids causes deep dystrophic changes of exocrine pancreocyte, including loss of regular form, karyopyknosis and karyorrhexis of nuclei, swelling and enlightenment of cytoplasm, the development of microcysric degeneration of the sells, loosening and disorganization of basal membrane which may lead to the disturbance of exocrine function of pancreas and difficulties of the process of elimination of secretory granules into the lumen of the inserted ducts. The work is a base for further researches of morphologists and clinicians to develop new diagnostic methods in the future, prevention and treatment of the pancreas diseases of drug addicts and patients who had to take opioids for a long time.
How to cite this article:
P. Popyk, L. Mateshuk-Vatseba. Dynamics of ultrastructural changes exocrine part of rat pancreas under the influence of opioid. Pharma Innovation 2015;4(4):63-65.