Vol. 4, Issue 4 (2015)

Author(s):
Rashmi G Kolli, V M Reddy, C.C. Patil, R.V. Kulkarni, N.V. Kalyani

Abstract:
Matrix tablets are providing the promising way to decrease the side effect of drug by preventing the fluctuation of therapeutic concentration of the drug in the body. The main objective of the study was to develop matrix tablet of Ramiprill. Tablets of Ramiprill were prepared by the wet granulation method using polymers like Hydroxy propyl methylcellulose, Ethyl cellulose, Guar gum in different ratios. Matrix tablet were evaluated by different methods for parameters such as thickness, hardness, weight uniformity, drug content uniformity, and in vitro drug release studies, stability studies. The tablets were evaluated for in vitro release in pH7.4 phosphate buffer for 12 hours in standard dissolution apparatus. Mucoadhesion strength is increased with increase in the concentration of HPMC and in combination of polymers. In order to determine the mode of release, the data was subjected to Zero order, First order, Higuchi and Peppas diffusion model. Short term stability studies on the promising formulation indicated that, there are no significant changes in drug content. IR spectroscopic indicated that there are no drug- excipients interaction. All the granules of the formulation showed in compliance with Pharmcopeial Standards. The developed sustain released matrix tablet of Ramipril drug showed 12 hours of drug release and overcome the disadvantage of conventional tablets.