Vol. 4, Issue 4 (2015)

Author(s):
Sunil kumar B, Chandrashekar C Patil, Mithun H, Pramod Bagi, Manmataya S, Umashree D

Abstract:
The present study was aimed at development of mucoadhesive gastro retentive tablets of Cefpodoxime Proxetil for controlled release and to develop innovative and suitable dosage form by the use of various polymers. Cefpodoxime Proxetil is an oral third generation cephalosporin antibiotic and is active against most Gram positive and Gram negative bacteria but it undergoes rapid metabolism in intestinal mucosa due to change in pH environment and hence decreased oral bio-availability. Different tablet formulations were prepared using different mucoadhesive polymers like Carbopol 974P, Chitosan, HPMC K4M and Sodium alginate in various combination ratios by direct compression method. All the developed formulations were subjected to various evaluation parameters such as physicochemical properties. Optimized formulation was decided based on drug release studies and gastric residence time. Formulation containing Sodium alginate and chitosan in combination (F8) exhibited maximum in vitro residence time of 10 hrs and in vitro release was up to 91%. Optimized formulation was further subjected to in vitro permeation, SEM studies and stability studies. Scanning Electron Microscopy (SEM) revealed smooth surface characteristics with increasing pore diameter indicating the diffusion mechanism of release. Stability studies was carried out as per ICH.