The study of the analgesic properties of combined aerosols with the propolis phenolic hydrophobic drug in the experiment
О. S. Shpychak, A. I. Tikhonov, I. A. Zupanets, S. K. Shebeko
The article presents the results of the experimental study of the analgesic properties of model samples of combined aerosol drugs with the cooling action, which contain the propolis phenolic hydrophobic drug (PPHD) and topical anaesthetics as the main active ingredients. The samples studied are intended for external use in order to remove the pain syndrome in traumas occurring mainly in sports medicine and extreme conditions.
The results of the study have demonstrated the essential role of halocarbons in the final analgesic activity of the drugs under research. Thus, the optimal content of topical anaesthetic is 3.0% because the aerosols containing 3.0 g of lidocaine hydrochloride or articaine hydrochloride show the analgesic activity at the level of the experimental sample containing 5.0 g of articaine hydrochloride.According to the results of the researches conducted, as well as for reasons of stability of the dosage forms of the samples studied it has been found that the sample containing 10% solution of PPHD in propylene glycol and 3.0% of lidocaine hydrochloride is the most appropriate for further development of the aerosol drug.
How to cite this article:
О. S. Shpychak, A. I. Tikhonov, I. A. Zupanets, S. K. Shebeko. The study of the analgesic properties of combined aerosols with the propolis phenolic hydrophobic drug in the experiment. Pharma Innovation 2015;4(3):78-81.