Vol. 4, Issue 3 (2015)

Author(s):
K. M. Tkachenko, I. A. Zupanets, S. K. Shebeko, I. A. Otrishko, Ye. F. Grintsov

Abstract:
The article presents the results of the experimental study of the acute toxicity of tetracyclines. The tasks of this study were to conduct the comparative analysis of safety as well as finding the median lethal dose (LD50) of tetracycline hydrochloride, doxycycline hydrochloride, methacycline hydrochloride and to determine the optimal remedy for the further studies as anti-inflammatory and chondroprotective drug. It has been found that the LD50 of tetracycline hydrochloride after single oral administration in rats is 1478.22±201.67 mg/kg, LD50 of doxycycline hydrochloride – 1893.03±286.20 mg/kg and LD50 of methacycline hydrochloride – 1635.73±199.36 mg/kg. Thus, doxycycline is significantly safer than tetracycline and methacycline.