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Vol. 4, Issue 10 (2015)

Preparation and in-vitro evaluation of nifedipine amorphous solid dispersions using mesoporous silica gel

Author(s):
Bhargavi L, Prathusha P, Belsen David, Yogesh S Chaudhari, Uppendra Reddy, Ajith Patil, Fred Monsuur
Abstract:
The main purpose of this study was to increase the solubility of poorly soluble drug by preparing solid dispersions. Nifedipine (poorly water soluble drug), when prepared as solid dispersion showed increased solubility and dissolution rate. Solid dispersions of Nifedipine were prepared by using silsol 6035 as carrier in various proportions 10%, 20% and 30% by solvent loading (solvent droplet addition)method and various grades of silica by co-milling method in ratios of (1:1, 1:2 and 2:1). The drug carrier interactions were carried out using Differential Scanning Calorimetry (DSC). Drug release and dissolution profile was studied and it was found that the percentage release of the drug for solid dispersions samples was found to be higher than those of the pure milled drug and co-milled powders.
Pages: 88-92  |  1133 Views  12 Downloads
How to cite this article:
Bhargavi L, Prathusha P, Belsen David, Yogesh S Chaudhari, Uppendra Reddy, Ajith Patil, Fred Monsuur. Preparation and in-vitro evaluation of nifedipine amorphous solid dispersions using mesoporous silica gel. Pharma Innovation 2015;4(10):88-92.
The Pharma Innovation Journal