Vol. 4, Issue 1 (2015)

Author(s):
Ashish Gorle, Prafulla Patil, Rajveer Bhaskar, Monika Ola

Abstract:
The present study illustrates development of site specific delivery of metoprolol succinate in treatment of hypertension. Formulations were developed by utilizing polymers such as HPMC and Chitosan along with plasticizer (PEG-400) by solvent technique. The calibration curve of metoprolol succinate was developed in PBS pH 6.8 at 223 nm in the range of 5 to 25 µg/ml. Compatibility study were carried out by FT-IR and Differential scanning colorimetry. The formulations were evaluated for thickness, folding endurance, weight variation, drug content, percent moisture loss, percent moisture absorption, tensile strength, SEM. In vitro drug diffusion study was also carried out using franz diffusion cell with PBS pH 6.8 and the samples were analyzed by UV-spectrophotometrically at 223 nm. FT-IR and DSC study revealed no interaction between drug and polymers. Formulations shown good uniformity of drug content more than 90%, there is little effect on moisture loss test due to hydrophilic polymers. Formulations showed thickness within the range of 0.17 to 0.28 in (F1, F2) HPMC. Whereas with ethyl cellulose thickness found to be 0.30, 0.35 mm respectively. All formulation showed good tensile strength. By increasing the concentration of polymer in the formulation increases the tensile strength, and folding endurance. But with use of ethyl cellulose it decreases the tensile strength. The buccal film formulated with 1:1 and 2:1 ratios of EC and HPMC, EC and CHITOSAN predominantly occurred by a diffusional process. This method could be used as an effective alternative delivery system for Metoprolol succinate when compared with conventional tablet formulations.